The term neuroimmune disease refers to a group of illnesses that are the result of acquired dysregulation of both the immune system and the nervous system, often resulting in lifelong disease and disability.

Symptoms may include:

• abdominal pain
• disordered sleep
• muscle fatigability & weakness 
• mild to severe cognitive impairment
• nausea
• orthostatic intolerance (OI)
• painful nerves, joints and or muscles
• post exertional neuroimmune exhaustion
• postural orthostatic tachycardia (POTS)
• reactivated viruses and opportunistic infections
• severe headaches/migraines 
• sore throat
• swollen lymph nodes
• unusual fatigue

Complex Immune & Neuro Diseases

This is a only a sample list of complex immune and neuroimmune diseases. There are many other diseases that may fall under this criterion.  

These diseases most often follow an infectious or flu-like illness, that does not fully resolve after standard treatment or over a typical course of time.

Challenges to the immune system, such as new or reactivated infections, major life stresses or exposure to toxins, can trigger a severe relapse or worsening of existing symptoms.

Neuroimmune diseases such as myalgic encephalomyelitis and Chronic Fatigue Syndrome are acquired disorders, that impact the body and the brain. They are on the rise and can last a lifetime.

Similarly to myalgic encephalomyelitis, other neuroimmune conditions have devastating effects on the body and mind. These diseases impact tens of millions of people around the world. Yet, those who suffer have no mainstream medical establishment approved treatments for underlying causes of the diseases or methods to prevent others from becoming ill.

Neuroimmune diseases such as those listed below, deserve significantly higher research priority. More research is needed to identify and develop biomarkers of these diseases, so that more effective treatments can become available for those who suffer.

Disease Prevalence 

• Autism Spectrum Disorder (ASD) 
  
  • 1 in 36 children in the United States are estimated to have an ASD diagnosis. 
    • 1 in 36: ASD Rate Set a New Record High in 2016 -- blog by Mark Blaxill
    • Autism Rate Jumps to 1 in 36 Children, 1 in 28 Boys -- blog by Dr Bob Sears
    • NCHS Data Brief Tables, Number 291, December 2017 -- CDC 
  • 1 in 66 children in Canada are estimated to have an ASD diagnosis.
    • Autism Prevalence among Children and Youth in Canada -- 2018 Report of the National Autism Spectrum Disorder (ASD) Surveillance System
  • 1 in 160 worldwide are are estimated to have an ASD diagnosis.
    • Autism spectrum disorders -- World Health Organization
  • These figures do not include other deaths or injuries caused by vaccine injury 
    
    
• Fibromyalgia (FM)
  • 6 to 12 million people in the United States are estimated to have a FM diagnosis.
    • Quick Facts on Fibromyalgia -- American Pain Association
  • 900 thousand Canadians are estimated to have a FM diagnosis.
    • Musculoskeletal diseases: Fibromyalgia -- archived Health State Descriptions for Canadians
  • 230 - 460 million (3-6% of world population)  people world wide are estimated to have a FM diagnosis.
    • Fibromyalgia Prevalence --  -- National Fibromyalgia Association
      
      
• Gulf War Illness (GWI)
  • Approximately 250,000 of the 697,000 U.S. veterans who were enlisted in the 1991 Gulf War ended up with a severe chronic illness similar to the symptoms of ME 
    • Gulf War Illness and the Health of Gulf War Veterans: Scientific Findings and Recommendations -- Research Advisory Committee on Gulf War Veterans’ Illnesses, Washington, D.C.: U.S. Government Printing Office, November 2008
    • Gulf War Syndrome -- Wikipedia
    • ~935,000 Coalition of the Gulf War troops
      • Coalition of the Gulf War -- Wikipedia
    • 30% of the men and women who served during the conflict
      • Gulf War Syndrome and How It Affects Veterans -- by Robert Rivera, 10 Mar 2020, Hill & Ponton Disability Attorneys website. “Veterans from every country that made up the Coalition forces have been affected. In the US alone, more than 110,000 cases had been reported by 1999, according to official government sources. It is estimated that it may affect as many as 30% of the men and women who served during the conflict. While the exact cause remains unknown, the same study found that veterans who experience these symptoms also experienced a loss of brain matter. (1)”
• Lyme Disease
  
  • USA Prevalence: It is estimated that there are 1,000,000 new cases of Lyme disease per year in the USA. This is estimated from the reported CDC survey of large commercial laboratories that only identifies only 15-30% of the cases (about 300,000 cases per year) due to 70-85% of those tests are false negative results. Only 30,000 of the large commercial laboratory tests are reported to the CDC. Of the 1,000,000 new cases, 500,000 go on to become chronic infection due to failed treatments including antibiotics.
    • The CDC estimates 300,000 new Lyme Diseases cases a year.
      • CDC Lyme Disease: Data and Surveillance Webpage
    • Lyme disease is a fast growing epidemic in the U.S. (Many sufferers go on to develop a chronic illness identical to ME.)
      • Predicting Lyme Disease, the Fastest Growing Infectious Disease in the U.S. A Climate-Based Classification Model to Address the Quiet Epidemic by Tristan Bonds
  • World wide prevalence of Lyme disease
    •  Brave New Worlds: The Expanding Universe of Lyme Disease -- Vector Borne and Zoonotic Diseases Journal, 1 Sep 2017
  • Due to highly inaccurate testing, the numbers presented by the CDC are grossly under counted. 
    • Dattwyler & Duray published that treatment fails in half the cases, IDSA's journal, 1989:
      
      • “Clinical studies have documented the efficacy of antibiotics, but therapy has failed in as many as 50% of cases of chronic infection.” 
        •  Abstract: A perspective on the treatment of Lyme borreliosis.
      • Full article:
        • "However, of patients with severe neurologic signs, such as spastic paraparesis, more than 50% will continue to suffer from disability due to this disease for months to years after treatment (44, 45). It is not clear whether this long-term effect is due to a persistent, smoldering infection; to immune autoreactivity triggered by the infection; or to pathologic changes that occur prior to treatment. Similarly, antibiotic treatment of acrodermatitis atrophicans produces resolution of skin involvement in only 50% of patients. In addition, -50% of these patients continue to have extracutaneous manifestations of Lyme disease after therapy [8]. Thus, failure rates of >50% are being reported in some series for the treatment of chronic rheumatologic, dermatologic, or neurologic disease due to B. burgdorferi. Clearly, alternative therapies are needed". 
          • A Perspective on the Treatment of Lyme Borreliosis from JSTOR archive.
      • "Six months after treatment, 15 of the 29 patients in the study had fully recovered, while 13 had persistent symptoms, and one had dropped out."
        • Lyme Disease May Be Diagnosable via Transcriptome Signature -- GEN: Genetic Engineering & Biotechnology News, 12 Feb 2016
          
          
• Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS)
  • 836,000 to 2.5 million Americans are estimated to have a ME/CFS diagnosis. 
    • What is ME/CFS? -- CDC
    • Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning -- Frontiers in Pediatrics Journal, 2018
  • 580 thousand Canadians are estimated to have a ME/CFS diagnosis. 
    • Chronic Fatigue Syndrome -- -- archived Health State Descriptions for Canadians
  • 17 million people worldwide are estimated to have a ME/CFS diagnosis.
    • How many people have ME/CFS? -- ME Research UK

World Wide CIND Prevalence 

World Population:  ~7,780,000,000

• Autism Spectrum Disorder:  48,625,000 (7,780,000,000/160)
• Fibromyalgia:  466,800,000 (6% of 7,780,000,000)
• Gulf War Illness:  285,900 Coalition Troops (30% of 935,000)
• Myalgic Encephalomyelitis & Chronic Fatigue Syndrome: 17,000,000

Total World CIND Prevalence = 532,710,900*

*Does not include: Chronic & Late Stage Lyme disease, only have 500,000 per year USA diagnosis estimates