Lyme disease, or neuroborreliosis, has left millions of people to suffer when it becomes chronic or late stage. Lyme disease is rarely the only infection patients have after becoming ill. People with Lyme often carry a variety of co-infections and become prone to latent viral and opportunistic infections.
Due to lipoproteins shed by Lyme spirochetes, a large number of people who have this debilitating disease often end up with an impaired immune system that is unable to keep reactivated viruses and opportunistic infections at bay.
Lipoproteins that are shed by spirochetes are ignored by both the Infectious Diseases Society of America (IDSA) guidelines that are used by the Centers for Disease Control and Prevention (CDC), and the International Lyme and Associated Diseases Society (ILADS). These facts are missing in their case definitions of Lyme disease. Victims of this outcome are frequently misdiagnosed or denied any diagnosis or proper treatment.
The only CDC-sanctioned Lyme disease testing is ANTIBODY based. People whose immune systems are damaged (immunosuppression) don't produce the required antibodies to attain a positive CDC test.
The currently used “Dearborn” case definition was put in place in 1994, when the now-failed Lyme vaccine (LYMErix) was in the clinical trial stage.
LYMErix Vaccine Victim's Stories~FDA Jan. 2001 (Click Here)
For the LYMErix vaccine, the CDC used OspA/Pam3cys (a highly acylated lipoprotein, TLR2/1 agonist; triacylated, that's also shed by the organisms that cause Lyme disease) and it caused adverse events. These adverse events led vaccine injured patients to have symptoms that looked exactly like what we know as "chronic Lyme disease" or "post-treatment Lyme disease syndrome (PTLDS). Same as being bitten (injected) by a tick.
Photo credit: Chris & Denise Overholt -- Late stage LD patient protests IDSA LD guidelines.
In the Lyme world, there are currently two different definitions of Lyme disease. The ILADS model, and the IDSA model do not take into account the mechanisms of disease as demonstrated by the LYMErix debacle. They both fail to address the key mechanisms of the disease: Immunosuppression.
- The IDSA (1994 CDC falsified "Dearborn" still being used today)
- The ILADS definition Lyme Disease Basics for Providers: A Brief Primer by International Lyme and Associated Diseases Society.
Both IDSA and ILADS portray Lyme disease as a treatable infection, when in actuality only 50% respond to treatment, and usually is only a temporary improvement in symptoms. These definitions keep millions sick, many disabled, and for some shortens their lifespan. These definitions also are preventing proper diagnosis for millions of current and future tick-borne illnesses.
Proposed 3rd definition by May12.org: (Click Here)
Here is the Science Behind Why a Lyme Vaccine Will Harm:
The new #Lyme #Vaccine will cause injuries. It still has #Pam3Cys on it. Every vaccine made with triacylated lipoproteins has failed in the same exact way. "Pretreatment of WT macrophages with Pam3Cys, a TLR2-TLR1 agonist, ablated p-p38 and p-JNK in response to challenge with Pam3Cys and LPS, whereas IRAK4(KDKI) macrophages exhibited attenuated TLR2-elicited homo- and heterotolerance at the level of MAPK activation. Thus, IRAK4 kinase activity is not required for the induction of endotoxin tolerance but contributes significantly to TLR2-elicited homo- and heterotolerance."
- IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance. -- J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.
- "These results show that signaling through TLR1/2 in response to B. burgdorferi can elicit opposite immunoregulatory effects in blood and in brain immune cells, which could play a role in the different susceptibility of these compartments to infection."
"Toll-like receptors (TLRs) trigger innate immune responses via the recognition of conserved pathogen-associated molecular patterns. Lipoproteins from Borrelia burgdorferi, the agent of Lyme disease, activate inflammatory cells through TLR2 and TLR1. We show that stimulation of human monocytes with B. burgdorferi lysate, lipidated outer surface protein A, and triacylated lipopeptide Pam3CysSerLys4 results in the up-regulation of both TLR2 and TLR1 but the down-regulation of TLR5, the receptor for bacterial flagellin, and that this effect is mediated via TLR2. TLR4 stimulation had no effect on TLR2, TLR1, and TLR5 expression. Human monocytes stimulated with TLR5 ligands (including p37 or flaA, the minor protein from B. burgdorferi flagella) up-regulated TLR5. In addition, TLR2 stimulation rendered cells hyporesponsive to a TLR5 agonist. These results indicate that diverse stimuli can cause differential TLR expression, and we hypothesize that these changes may be useful for either the pathogen and/or the host.
- "Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. -- J Infect Dis. 2006 Mar 15;193(6):849-59. Epub 2006 Feb 8.
"The OspA and OspB antigens were radioimmunoprecipitated from [3H]palmitate-labeled detergent-phase proteins with monoclonal
antibodies, and [3H]palmitate was recovered unaltered from these proteins after sequential alkaline and acid
hydrolyses. The combined results provide formal confirmation that the major B. burgdorferi immunogens
extracted by Triton X-114 are lipoproteins. The demonstration that B. burgdorferi integral membrane antigens
are lipoproteins may explain the basis of their immunogenicity and may help to improve our understanding of
the surface topology of B. burgdorferi.
Immunogenic Integral Membrane Proteins of Borrelia burgdorferi Are Lipoproteins -- INFECTION AND IMMUNITY, Apr. 1990, p. 983-991 Vol. 58, No. 4
0019-9567/90/040983-09$02.00/0 Copyright ©D 1990, American Society for Microbiology.
- Immunogenic Integral Membrane Proteins of Borrelia burgdorferi Are Lipoproteins -- INFECTION AND IMMUNITY, Apr. 1990, p. 983-991 Vol. 58, No. 4
"The data suggest a role for the native protein in cellular activation by these ligands. In addition, TLR2-dependent responses were seen using whole Mycobacterium avium and Staphylococcus aureus, demonstrating that this receptor can function as a signal transducer for a wide spectrum of bacterial products. We conclude that diverse pathogens activate cells through TLR2 and propose that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion."
- Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products -- doi: 10.1074/jbc.274.47.33419November 19, 1999The Journal of Biological Chemistry274, 33419-33425.
The main ingredient in the Lyme vaccine is OspA which is the very same thing that makes people chronically ill from a tick bite. You cannot vaccinate with or against OspA - a fungal-like endotoxin.
Just ask the many victims of LYMErix (1998-2001) who were made chronically ill.There’s plenty of FDA testimony to this effect. See link above: "LYMErix Vaccine Victim's Stories~FDA Jan. 2001"
SHORT VERSION of “the disease is caused by the vaccine.” Lyme and LYMErix disease = same post-sepsis syndrome. -- article by
Lyme Disease, Persistence, and Immunosuppression
Peer Reviewed Evidence of Persistence of Lyme Disease Spirochete Borrelia burgdorferi and Tick-Borne Diseases
- 230 peer-reviewed studies show evidence of persistent Lyme disease -- Norvect website
- This ILADS list has over 700 peer reviewed articles that support the evidence of persistence of Lyme and other tick-borne diseases. It is organized into different categories—general, psychiatric, dementia, autism and congenital transmission.
It is important for people to understand WHY Lyme disease is persistent.
First priority to open up the floodgates so all Lyme victims can receive proper recognition, proper disability evaluations, and adequate treatments:
1. REMOVAL of the falsified Lyme disease case definition AKA "Dearborn" -1994, which would eliminate the fraudulent two-tier Lyme testing (which misses most neurological Lyme patients).
- How did Steere leave Osp A and B out of diagnostic standard? -- webpage documenting Steere leaving out Osp A and B from ActionLyme.org - The Lyme Cryme Whistleblower's Website
- Science Links -- published studies on Lyme disease
- Lyme Scientists -- those who have published literature on the immune suppressing effects of OspA
Bitten: The Secret History of Lyme Disease and Biological Weapons -- by Kris Newby, Hardcover 14 May 2019
Cure Unknown: Inside the Lyme Epidemic -- by Pamela Weintraub, Paperback 13 Oct 2019
Gone in a Heartbeat: A Physician's Search for True Healing -- by Dr. Neil Spector, Paperback 29 Jan 2015
Lab 257: The Disturbing Story of the Government's Secret Germ Laboratory -- by by Michael C. Carroll, Paperback 9 Aug 2005
Lyme Madness: Rescuing My Son Down The Rabbit Hole of Chronic Lyme Disease. -- by Lori Dennis, Paperback – November 15, 2016
Out of the Woods Healing from Lyme Disease for Body, Mind, and Spirit-- by Katina I. Makris, foreword by Richard Horowitz
Unlocking Lyme: Myths, Truths, and Practical Solutions for Chronic Lyme Disease -- by William Rawls
WEBSITES, BLOGS, & ARTICLES:
What is Lyme Disease? - a directory for Tick Borne Information - recommended for people starting to learn about Lyme disease
ActionLyme.org -- The Lyme Cryme Whistleblower's Website
Cryme Disease -- Blog about Unscrambling the CDC's DNA Patent Profiteering Bullshit
Explaining CDC fraud and diseases of abuse & denial (Lyme, ME/CFS, Gulf War Illness, and vaccines-acquired Autism)
All Things Lyme Blog -- by Daniel Cameron MD
Jen vs. Lyme Disease Blog - Overcoming Lyme Disease through Holistic Healing -- by Jennifer Darr
Lori Dennis Online - author of Lyme Madness -- by Lori Dennis, MA, RP: psychotherapist, author, speaker, Lyme Activist. Dedicated to Affirming & Empowering Those who Suffer from Lyme Disease & Other Unexplained Illnesses
- Lyme Disease Misdiagnosed As...-- Did you know there are 300 conditions which mimic Lyme disease? This list is critical because if someone is suffering from one of these conditions, they should be tested for Lyme disease!
ResearchFraud.com -- Research Fraud in Two-Tier Lyme Testing and Vaccine
The Other Side of the Stretcher -- blog, Nurse Turned Patient Living Life on the Other Side of the Stretcher since 1995!
VitalPlan.com Blog -- by Bill Rawls, MD
When Lyme Disease Lasts and Lasts - The New York Times --By Jane E. Brody, July 8, 2013
- "Often misdiagnosed and mistreated, chronic Lyme disease leaves thousands of people physically and mentally debilitated and without a medically established recourse."
Global Science Blog -- International blog that provides info on the science of ME, CFS, Lyme, Fibromyalgia, Gulf War Illness, etc.
Lyme Crime Downloads -- ActionLyme Charge Sheet Cliff Notes on Overcoming Lyme Disease website by Jennifer Heath
Lyme Cryme: How it all Went Down -- article by Erin Elizabeth, on Erin at Health Nut News, 15 Mar 2017
Calling for a Congressional investigation of the CDC, IDSA and ALDF -- petition started by Carl Tuttle, over 98,180 signed. Please sign if you haven't already!
We also recommend using these hashtags when sharing on social media:
#May12CureCIND #LymeDisease #Lyme #LYMErix #OspA #Pam3Cys #Valneva #ReactivatedViruses #OpportunisticInfections #ScienceFraud #MedicalFraud #ResearchFraud #ImmuneDeficiency #ImmuneSuppression #ActUp4Lyme #May12
@May12org -- Supporting #PwME #Lyme disease #VaccineInjury #GWI #PostSepsis *Complex Immunologic & Neurologic Diseases #ImmuneDeficiency #ReactivatedViruses #Science.
@RawlsMD -- Bill Rawls, MD: Piecing together the puzzle of invisible illness after pulling myself out of a ten-year struggle with Chronic Lyme & Fibromyalgia.
@CanLyme -- The Canadian Lyme Disease Foundation is dedicated to promoting research, education, diagnosis and treatment of Lyme and associated diseases in Canada.
@drneilspector -- Dr. Neil Spector
@LymeBook -- Dr. Steven Phillips & Dana Parish: Top Yale-trained MD & chart-topping Sony/ATV songwriter, coauthors of: ‘CHRONIC: The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again’.
@LymeBloggers -- Hundreds of blogs being written by Lyme Disease patients all combined into one feed of the most recent posts.
@lyme_protest -- Official_Lyme_Disease_Protest_UK: Lyme Protest 💚FIGHT BACK 2020💚 #LymeDenial #Gaslighting #Misdiagnosis #LymeTesting failed #NoTreatment #lyme #lymedisease #ChronicIllness #pandemic.
@LymeMadness -- Lori Dennis: Lyme Madness™ is authored by Lori Dennis, M.A. Psychotherapist - a 'mom on a mission' to help you understand the complexities of Chronic Lyme Disease.